Video / Screenshot: None
Reproduction steps: A Ryze with Zhonyas, Lvl 6+ and a Karma.
The Situation: Ryze channels his R, Karma chains him, Ryze goes into Zhonyas.
Expected result: Ryze travels within his Ultimate, with Zhonyas activated, without problems or interruption.
Observed result: The Karma chains second Proc interrupts Ryze's Ultimate, even though he successfully started channeling it and entered Zhonyas. He doesn't teleport.
Reproduction rate: 10/10