Is it hard to learn the midrole?

I can play pretty much every role except for mid . I don't know why , I just never tried it. However there are some pretty cool champs that I'd like to play such as Vel'koz, Fizz, Katarina, Veigar and Cassiopeia. But is it difficult to play the midrole? What is the easiest champ to start learning here?
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