I never really felt I was at a huge disadvantage, I never suffered from being vs/against premades. Another thing is that I can FINALLY play ranked with any number of my friends, previously I got punished for wanting to have fun with 2 or more friends. "You want to play and have fun with 2 other people? guess you'll have to settle for normals then" which was mostly the reason I never climbed that high before (more than 1 friend were on most of the time, I simply have more fun playing with friends).
Is being vs 3 or 4 premades really that bad? especially since the system does do a decent job at matching premades against premades for the most part.