Side By Side Configuration Incorrect

Had an issue with LoL last night that I got fed up with, reinstalled the game, patched it to the latest Client etc etc Now I click the League icon on Desktop, it shows me the old launcher. I click "Play" and nothing. Go into file location, open LeagueClient and I get the error "Cannot launch, side by side configuration is incorrect". I've never once had this problem before and it's beginning to seriously annoy me. I removed every last trace of LoL from my computer, installed it all fresh and I'm getting the same issue over and over and over. Any fix? I did look and the suggestion is to install some vcredist but even that didn't work so... I'm stumped.
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